Birth Defects: Of Zofran and Cleft Lip and Palate

Feb 02

There is still a lot of prevalent prejudice in this world’s society still present today and a lot of that comes from the perception of physical attributes. Many people are criticized if their features are not totally symmetrical or have a culturally acceptable skin color. Ever crueler can people be towards those few unfortunate people who are born with physical defects.

One of these physical defects is being born with a cleft lip and palate. If the palate is not involved, then it is only called a cleft lip. This is commonly a birth defect and can be corrected via surgery. Should the medical procedure be a success, the child in question would not even bear the scar of this affliction upon growing up. However, this is a medical procedure that has been known to be costly and many families, already burdened financially, cannot bear the expense that this procedure will cost.

Though there are cases wherein the defect is due to a genetic anomaly, there has been newfound evidence that links the fetuses’ exposure to certain medications that cause this unfortunate situation for the child. According to the website of Williams Kherkher, Zofran is one of these drugs.

Zofran is popularly prescribed to people who experience nausea due to some illness or due to the fact that it is a side effect of some medical treatment or some other medication. Cancer patients, for example, often experience nausea after chemotherapy or radiation and are therefore prescribed this drug in order to steady their food intake.

Pregnant women are also people who experience constant nausea and often resort to this medication as it is quite effective and works quickly. However, there have been some cases linking some birth defects as a result of consumption of the drug with ondansetron hydrochloride during the early development stages of the fetuses. Some of these defects include cleft lip and palate, as well as potentially lethal defects such as that of congenital heart defect.

If you or someone you know is currently suffering from a similar situation, it is recommended to look for specialized legal assistance immediately in order to know what are the rights owed to you for having to suffer this kind of consequence from this medication.

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Xarelto Studies Designed to Expand Market

Sep 04

Despite thrice being rejected by the Food and Drug Administration (FDA), Johnson & Johnson and Bayer AG are pushing through with clinical trials to make a renewed bid to get approval for its anticoagulant product Xarelto (rivaroxaban) for acute coronary syndrome (ACS). The drug is already approved for ACS treatment in 40 countries outside the US, but the FDA is proceeding with caution with this one.

Perhaps this is because there is a rising tide of discontent against the drug with American patients; the first lawsuits have already been filed claiming that it posed unacceptable levels of danger to patients for its approved uses, primarily for management of atrial fibrillation, deep vein thrombosis, and clot prevention following hip or knee replacement surgery. According to the website of law firm Williams Kherkher, however, the exclusion of ACS as an approved condition for prescription is not limited to Xarelto but for all drugs in the same class, namely direct factor Xa inhibitors or xabans. This could partly be due to the fact that there is no approved reversal agent for this class of drug in case of serious adverse effects, such as uncontrollable bleeding.

The latest attempt by J&J and Bayer to get approval for ACS in March 2014 ran into trouble when the clinical trials presented to the FDA contained inconsistencies in the data that failed to clarify the extent of the benefits and risks of the drug, and the application was denied. Undaunted, J&J and Bayer came up with a different clinical trial design using one antiplatelet drug in conjunction with Xarelto instead of two which is thought will reduce the risk of blooding and will hopefully pass muster in the future. Aside from ACS, the two companies are also hoping to get approval for Xarelto for stroke and peripheral artery disease.

If the FDA issues approval for all pending applications for Xarelto, this would bring the total of all approved conditions for prescription for the drug to 12. That is a potentially huge market; Xarelto is already outpacing its competition for its approved uses. Whether it gets approved for more conditions, Xarelto is already taking a significant slice of the market. Not surprisingly, there are also a growing number of lawsuits being filed against the two companies because of the serious harm the drug has inflicted on some patients. If you have been seriously harmed from using Xarelto, consult with a Xarelto lawyer at once to find out what can be done to compensate you for your medical expenses and losses.

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From the Frying Pan to the Fire: E-liquid toxicity causes concern

Apr 09

People are now much more health conscious, and are actively seeking ways to improve their quality of life. The trend is for eating organic food and food products, exercising regularly, having regular detoxification sessions, minimizing alcohol intake, and of course, quitting smoking. But just like saccharine for sugar, and soy milk for cow’s milk, sometimes the substitutes turn out to be more harmful than what had been replaced. In the case of cigarettes, the solution to minimizing withdrawal symptoms is through electronic cigarettes, or e-cigarettes.

E-cigarettes are basically plastic tubes that dispense small amounts of nicotine by atomizing a liquid which contains the chemical as well as flavoring and artificial coloring, the so-called e-liquid. This is not a regulated industry, and anyone can legally make the e-liquid and sell it by the vial, bottle, or gallon.

But possible contamination is not really the problem. The real problem lies in the fact that nicotine is a poison, and in liquid form, it is more deadly than what you find in a standard cigarettes because it is more easily absorbed by the body.

E-cigarettes are touted as a smoking cessation tool, and e-liquid contains nicotine because this is what most smokers are addicted to which makes it difficult to quit smoking. With the nicotine hit in place, the smoker can gradually reduce the amount of nicotine in the e-liquid until finally, the symptoms subside and you are cured of the habit.

It sounds plausible, but it is more akin to jumping from the frying pan to the fire than the road to redemption. While no one has actually died from the prescribed or accidental intake of e-liquid, studies indicate that it is just a matter of time. There is already a trend emerging where out of the number of people being rushed to the emergency room after being poisoned from exposure to nicotine, a significant number are children between 1 and 4 years old. Toxicologists are all up in arms about the product, and it is claimed that e-liquids may be more hazardous to your health than tobacco.

Sometimes, it is better to stick with the evil you know.

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